Frank P. Pool, Michel A. Hofman, Louis J. Gooren, Dick F. Transsexuals experience themselves as being of the opposite sex, despite having the biological characteristics of one sex. A crucial question resulting from a previous brain study in male-to-female transsexuals was whether the reported difference according to gender identity in the central part of the bed nucleus of the stria terminalis BSTc was based on a neuronal difference in the BSTc itself or just a reflection of a difference in vasoactive intestinal polypeptide innervation from the amygdala, which was used as a marker. Therefore, we determined in 42 subjects the number of somatostatin-expressing neurons in the BSTc in relation to sex, sexual orientation, gender identity, and past or present hormonal status. In contrast, the neuron number of a female-to-male transsexual was found to be in the male range. Hormone treatment or sex hormone level variations in adulthood did not seem to have influenced BSTc neuron numbers.
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Materials and Methods
A trans woman sometimes trans-woman or transwoman is a woman who was assigned male at birth. Trans women may experience gender dysphoria and may transition; this process commonly includes hormone replacement therapy and sometimes sex reassignment surgery , which can bring relief and resolve feelings of gender dysphoria. Trans women may be heterosexual , bisexual , homosexual , asexual , or identify with other terms such as queer. The term transgender woman is not always interchangeable with transsexual woman , although the terms are often used interchangeably.
The Scientific World Journal
Sex reassignment surgery for male-to-female involves reshaping the male genitals into a form with the appearance of, and, as far as possible, the function of female genitalia. Before any surgery, patients usually undergo hormone replacement therapy HRT , and, depending on the age at which HRT begins, facial hair removal. There are associated surgeries patients may elect to, including vaginoplasty , facial feminization surgery , breast augmentation , and various other procedures. Lili Elbe was the first known recipient of male-to-female sex reassignment surgery, in Germany in She was the subject of four surgeries: one for orchiectomy , one to transplant an ovary , one for penectomy , and one for vaginoplasty and a uterus transplant.
It has been theorized that there are 2 subgroups within the male-to-female MtF transgender population: individuals who are predominantly androphilic and those who are predominantly gynephylic or interested in both male and female partners. To explore the role of a dichotomous distribution of age at dysphoria onset in individuals diagnosed with MtF gender dysphoria. Their age distribution was plotted as a histogram and the population was then divided at the median self-reported age of onset of gender dysphoria—that is, those 17 years and younger and those 18 years and older. The 2 groups were then compared with regard to demographic data, partnership history, various quality of life parameters, as well as sexual orientation and sexual history. Preoperatively, they showed greater depressive symptoms 4. Following surgery, the younger MtFs were predominantly attracted to men Younger trans individuals were more frequently sexually active Our findings suggest that there are 2 MtF populations that differ in age of dysphoria onset, sexual history, and multiple personal details including sexual orientation. These data may be used to improve care to transgender individuals by providing treatment reflecting their sexual interests.